RTW INVESTMENTS, LP
CIK 0001493215
Annualised vol
12.32667%
Beta
0.215075
HHI
337.276594
Top-10 weight
47.715362%
VaR 95%
1.024011%
VaR 99%
2.396746%
Max drawdown
27.566359%
Matched value
91.696569%
Holdings (latest quarter)
| Ticker | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|
| MDGL | MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 1,070,510,235 | 9.14 | 1993687.0 |
| ARGX | ARGENX SE | SPONSORED ADR | 04016X101 | 658,202,715 | 5.62 | 709446.0 |
| PTCT | PTC THERAPEUTICS INC | COM | 69366J200 | 631,875,072 | 5.39 | 7746415.0 |
| PTGX | PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 620,398,832 | 5.3 | 5061175.0 |
| CGON | CG ONCOLOGY INC | COM | 156944100 | 604,961,620 | 5.16 | 8514590.0 |
| INSM | INSMED INC | COM PAR $.01 | 457669307 | 516,347,866 | 4.41 | 4842880.0 |
| TNGX | TANGO THERAPEUTICS INC | COM | 87583X109 | 434,533,381 | 3.71 | 1.390062E7 |
| SYRE | SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 377,492,205 | 3.22 | 4251996.0 |
| CELC | CELCUITY INC | COM | 15102K100 | 345,758,952 | 2.95 | 3304903.0 |
| ERAS | ERASCA INC | COM | 29479A108 | 328,784,533 | 2.81 | 1.7946754E7 |
| RDNT | RADNET INC | COM | 750491102 | 298,911,900 | 2.55 | 4846958.0 |
| ORKA | ORUKA THERAPEUTICS INC | COM | 687604108 | 298,741,485 | 2.55 | 3139030.0 |
| NTRA | NATERA INC | COM | 632307104 | 271,450,000 | 2.32 | 1000000.0 |
| - | ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 260,338,324 | 2.22 | 7796895.0 |
| IRTC | IRHYTHM HOLDINGS INC | COM | 450056106 | 259,623,957 | 2.22 | 2182631.0 |
| CYTK | CYTOKINETICS INC | COM NEW | 23282W605 | 243,814,036 | 2.08 | 2862003.0 |
| KLRA | KAILERA THERAPEUTICS INC | COMMON STOCK | 482931102 | 237,413,345 | 2.03 | 1.077682E7 |
| - | ESTABLISHMENT LABS HLDGS INC | COM | G31249108 | 227,885,188 | 1.95 | 2655695.0 |
| GH | GUARDANT HEALTH INC | COM | 40131M109 | 222,199,381 | 1.9 | 1481033.0 |
| NBIX | NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 213,689,740 | 1.82 | 1267925.0 |
| TARS | TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 211,293,293 | 1.8 | 3357059.0 |
| STOK | STOKE THERAPEUTICS INC | COM | 86150R107 | 184,001,738 | 1.57 | 5623525.0 |
| - | UNIQURE NV | SHS | N90064101 | 181,548,806 | 1.55 | 3941572.0 |
| ACAD | ACADIA PHARMACEUTICALS INC | COM | 004225108 | 180,756,457 | 1.54 | 7144524.0 |
| RGEN | REPLIGEN CORP | COM | 759916109 | 169,272,512 | 1.45 | 1240637.0 |
| URGN | UROGEN PHARMA LTD | COM | M96088105 | 167,215,336 | 1.43 | 4543895.0 |
| GHRS | GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 159,500,947 | 1.36 | 5933815.0 |
| - | IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 154,616,087 | 1.32 | 4869798.0 |
| CMPS | COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 151,418,782 | 1.29 | 1.0700974E7 |
| IMTX | IMMATICS N.V | SHS | N44445109 | 131,144,763 | 1.12 | 1.2946176E7 |
| ZLAB | ZAI LAB LTD | ADR | 98887Q104 | 124,906,608 | 1.07 | 6574032.0 |
| IMVT | IMMUNOVANT INC | COM | 45258J102 | 122,442,522 | 1.05 | 3177849.0 |
| BLTE | BELITE BIO INC | SPONSORED ADS | 07782B104 | 110,150,398 | 0.94 | 715332.0 |
| XNCR | XENCOR INC | COM | 98401F105 | 109,117,122 | 0.93 | 6777461.0 |
| TSHA | TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 92,345,357 | 0.79 | 1.3560258E7 |
| COGT | COGENT BIOSCIENCES INC | COM | 19240Q201 | 89,359,113 | 0.76 | 2309021.0 |
| ALKS | ALKERMES PLC | SHS | G01767105 | 87,623,093 | 0.75 | 1672356.0 |
| GPCR | STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 86,274,901 | 0.74 | 1607507.0 |
| REPL | REPLIMUNE GROUP INC | COM | 76029N106 | 82,046,202 | 0.7 | 7411581.0 |
| CSTL | CASTLE BIOSCIENCES INC | COM | 14843C105 | 66,263,290 | 0.57 | 2778335.0 |
| CADL | CANDEL THERAPEUTICS INC | COM | 137404109 | 66,146,785 | 0.56 | 6422018.0 |
| RCKT | ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 60,492,180 | 0.52 | 1.7687772E7 |
| KOD | KODIAK SCIENCES INC | COM | 50015M109 | 57,969,909 | 0.49 | 1487934.0 |
| AKTS | AKTIS ONCOLOGY INC | COM | 01021M104 | 51,311,546 | 0.44 | 1592043.0 |
| AXGN | AXOGEN INC | COM | 05463X106 | 46,724,695 | 0.4 | 1011576.0 |
| - | DANAHER CORP DEL | COM | 235851102 | 43,810,400 | 0.37 | 230000.0 |
| CGEM | CULLINAN THERAPEUTICS INC | COM | 230031106 | 43,054,759 | 0.37 | 2364347.0 |
| NGNE | NEUROGENE INC | COM | 64135M105 | 42,849,241 | 0.37 | 1362456.0 |
| HNGE | HINGE HEALTH INC | CL A | 433313103 | 41,500,000 | 0.35 | 500000.0 |
| - | ORCHESTRA BIOMED HLDGS INC | COM | 68572M106 | 41,234,412 | 0.35 | 9556063.0 |
| SLDB | SOLID BIOSCIENCES INC | COM NEW | 83422E204 | 38,890,331 | 0.33 | 3892926.0 |
| SVRA | SAVARA INC | COM | 805111101 | 36,666,661 | 0.31 | 5952380.0 |
| AQST | AQUESTIVE THERAPEUTICS INC | COM | 03843E104 | 30,894,119 | 0.26 | 7426471.0 |
| KYMR | KYMERA THERAPEUTICS INC | COM | 501575104 | 27,520,800 | 0.23 | 240000.0 |
| VSTM | VERASTEM INC | COM NEW | 92337C203 | 25,348,729 | 0.22 | 6635793.0 |
| - | DIANTHUS THERAPEUTICS INC | COM | 252828108 | 24,181,181 | 0.21 | 248063.0 |
| BBNX | BETA BIONICS INC | COM | 08659B102 | 23,505,000 | 0.2 | 1500000.0 |
| IPSC | CENTURY THERAPEUTICS INC | COM | 15673T100 | 21,304,347 | 0.18 | 8695652.0 |
| EVMN | EVOMMUNE INC | COM SHS | 30054Y107 | 19,964,703 | 0.17 | 1502235.0 |
| BEAM | BEAM THERAPEUTICS INC | COM | 07373V105 | 19,575,922 | 0.17 | 570394.0 |
| DFTX | DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 | 18,816,000 | 0.16 | 400000.0 |
| IDYA | IDEAYA BIOSCIENCES INC | COM | 45166A102 | 13,803,690 | 0.12 | 370370.0 |
| - | ATAIBECKLEY INC | COM SHS | 04650F101 | 10,540,000 | 0.09 | 2000000.0 |
| - | MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | 10,496,670 | 0.09 | 7833336.0 |
| OCGN | OCUGEN INC | COM | 67577C105 | 10,199,999 | 0.09 | 6666666.0 |
| TENX | TENAX THERAPEUTICS INC | COM NEW | 88032L605 | 10,135,094 | 0.09 | 696570.0 |
| HTFL | HEARTFLOW INC | COM | 42238D107 | 8,655,300 | 0.07 | 295000.0 |
| - | PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 | 8,078,400 | 0.07 | 742500.0 |
| WVE | WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 7,843,500 | 0.07 | 1350000.0 |
| LRMR | LARIMAR THERAPEUTICS INC | COM | 517125100 | 7,826,297 | 0.07 | 2565999.0 |
| LMRI | LUMEXA IMAGING HOLDINGS INC | COM | 550249106 | 7,332,000 | 0.06 | 650000.0 |
| ALLO | ALLOGENE THERAPEUTICS INC | COM | 019770106 | 6,760,000 | 0.06 | 3250000.0 |
| CBIO | CRESCENT BIOPHARMA INC. | COM | G2545C104 | 6,711,408 | 0.06 | 372856.0 |
| - | 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 6,327,302 | 0.05 | 475737.0 |
| MAZE | MAZE THERAPEUTICS INC | COM | 578784100 | 6,326,080 | 0.05 | 212000.0 |
| CAPR | CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | 6,020,000 | 0.05 | 250000.0 |
| KLRS | KALARIS THERAPEUTICS INC | COM | 482929106 | 5,291,000 | 0.05 | 1300000.0 |
| - | ABIVAX SA | SPONSORED ADS | 00370M103 | 3,518,064 | 0.03 | 26400.0 |
| AVTX | AVALO THERAPEUTICS INC | COM NEW | 05338F306 | 3,234,000 | 0.03 | 175000.0 |
| MDLN | MEDLINE INC | COM CL A | 58507V107 | 2,760,800 | 0.02 | 70000.0 |
| IRON | DISC MEDICINE INC | COM | 254604101 | 2,194,200 | 0.02 | 30000.0 |
| IMA | IMAGENEBIO INC | COM | 45175G207 | 1,973,226 | 0.02 | 334445.0 |
| XGN | EXAGEN INC | COM | 30068X103 | 906,750 | 0.01 | 195000.0 |
| RCKT | ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | 77313F114 | 1,190 | 0.0 | 350000.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 11,712,926,784 | 84 | 12.32667 | 0.215075 | 27.566359 |
| 2026-03-31 | 2026-05-15 | 10,049,752,600 | 88 | 12.784193 | 0.26129 | 24.844421 |
| 2025-12-31 | 2026-02-17 | 9,983,316,876 | 91 | 12.452162 | 0.308986 | 18.025755 |
| 2025-09-30 | 2025-11-14 | 8,116,139,085 | 74 | 10.31638 | 0.263589 | 13.914163 |
| 2025-03-31 | 2025-05-15 | 6,538,371,722 | 68 | 10.78104 | 0.290651 | 14.211081 |
| 2024-12-31 | 2025-02-14 | 6,612,776,360 | 72 | 11.279966 | 0.297548 | 16.655716 |