BAKER BROS. ADVISORS LP
CIK 0001263508
Annualised vol
16.003215%
Beta
0.363987
HHI
764.089517
Top-10 weight
72.822971%
VaR 95%
1.498226%
VaR 99%
2.766149%
Max drawdown
28.002073%
Matched value
98.923337%
Holdings (latest quarter)
| Ticker | Issuer | Class | CUSIP | Value ($) | Weight % | Shares |
|---|---|---|---|---|---|---|
| INCY | Incyte Corporation | COM | 45337C102 | 3,487,217,729 | 17.48 | 3.076233E7 |
| ONC | BeOne Medicines Ltd. | SPONSORED ADS | 07725L102 | 2,508,182,548 | 12.57 | 8801567.0 |
| RVMD | Revolution Medicines, Inc. | COM | 76155X100 | 2,143,111,899 | 10.74 | 1.1443357E7 |
| MDGL | Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 1,150,754,190 | 5.77 | 2143131.0 |
| ACAD | ACADIA Pharmaceuticals Inc. | COM | 004225108 | 1,085,696,471 | 5.44 | 4.2912904E7 |
| KYMR | Kymera Therapeutics, Inc. | COM | 501575104 | 992,725,940 | 4.97 | 8657242.0 |
| INSM | Insmed Incorporated | COM PAR $.01 | 457669307 | 937,841,355 | 4.7 | 8796111.0 |
| CELC | Celcuity Inc. | COM | 15102K100 | 828,150,159 | 4.15 | 7915792.0 |
| KOD | Kodiak Sciences Inc. | COM | 50015M109 | 776,051,487 | 3.89 | 1.9919186E7 |
| RYTM | Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 622,265,747 | 3.12 | 5604483.0 |
| PRAX | Praxis Precision Medicines, Inc. | COM | 74006W207 | 586,953,158 | 2.94 | 1753198.0 |
| ALKS | Alkermes plc | SHS | G01767105 | 524,592,729 | 2.63 | 1.0012267E7 |
| SMMT | Summit Therapeutics Inc. | COM | 86627T108 | 477,697,090 | 2.39 | 3.2786348E7 |
| GRAL | GRAIL, Inc. | COM | 384747101 | 275,033,478 | 1.38 | 4028614.0 |
| ABCL | AbCellera Biologics Inc. | COM | 00288U106 | 259,145,283 | 1.3 | 3.3012138E7 |
| IMVT | Immunovant, Inc. | COM | 45258J102 | 209,419,027 | 1.05 | 5435220.0 |
| IDYA | IDEAYA Biosciences, Inc. | COM | 45166A102 | 186,723,818 | 0.94 | 5010030.0 |
| KNSA | Kiniksa Pharmaceuticals International, plc | ORD SHS CL A | G52694109 | 181,275,420 | 0.91 | 2834643.0 |
| ROIV | Roivant Sciences Ltd. | SHS | G76279101 | 166,928,649 | 0.84 | 4716831.0 |
| ARWR | Arrowhead Pharmaceuticals, Inc. | COM | 04280A100 | 162,431,742 | 0.81 | 1992783.0 |
| IONS | Ionis Pharmaceuticals, Inc. | COM | 462222100 | 162,364,274 | 0.81 | 2047727.0 |
| EWTX | Edgewise Therapeutics, Inc. | COM | 28036F105 | 150,400,843 | 0.75 | 3701719.0 |
| REPL | Replimune Group, Inc. | COM | 76029N106 | 122,271,870 | 0.61 | 1.1045336E7 |
| NRIX | Nurix Therapeutics, Inc. | COM | 67080M103 | 113,016,569 | 0.57 | 4658556.0 |
| STOK | Stoke Therapeutics, Inc. | COM | 86150R107 | 109,176,726 | 0.55 | 3336697.0 |
| GLUE | Monte Rosa Therapeutics, Inc. | COM | 61225M102 | 105,166,811 | 0.53 | 4345736.0 |
| IMTX | Immatics N.V. | SHS | N44445109 | 96,321,763 | 0.48 | 9508565.0 |
| DNLI | Denali Therapeutics Inc. | COM | 24823R105 | 96,047,122 | 0.48 | 3734336.0 |
| - | Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 87,991,820 | 0.44 | 2351465.0 |
| - | Dianthus Therapeutics, Inc. | COM | 252828108 | 83,068,947 | 0.42 | 852164.0 |
| GPCR | Structure Therapeutics Inc. | SPONSORED ADS | 86366E106 | 76,883,831 | 0.39 | 1432529.0 |
| CELC | Celcuity Inc. | Note 2.75% 8/1/2031 | 15102KAA8 | 69,158,687 | 0.35 | 3.075E7 |
| RAPP | Rapport Therapeutics, Inc. | COM | 75383L102 | 64,467,240 | 0.32 | 1547090.0 |
| ALMS | Alumis Inc. | COM | 022307102 | 56,631,750 | 0.28 | 2012500.0 |
| PRLD | Prelude Therapeutics Inc. | COM | 74065P101 | 53,959,982 | 0.27 | 1.0123824E7 |
| RLAY | Relay Therapeutics, Inc. | COM | 75943R102 | 52,889,110 | 0.27 | 2826783.0 |
| MIRM | Mirum Pharmaceuticals, Inc. | COM | 604749101 | 52,210,293 | 0.26 | 445975.0 |
| BCYC | Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | 46,153,914 | 0.23 | 1.0885357E7 |
| ELVN | Enliven Therapeutics, Inc. | COM | 29337E102 | 45,938,443 | 0.23 | 905191.0 |
| CLDX | Celldex Therapeutics, Inc. | COM | 15117B202 | 44,004,955 | 0.22 | 1182611.0 |
| - | Viridian Therapeutics, Inc. | COM | 92790C104 | 43,776,169 | 0.22 | 2383025.0 |
| DSGN | Design Therapeutics, Inc. | COM | 25056L103 | 38,756,882 | 0.19 | 2678430.0 |
| TRDA | Entrada Therapeutics, Inc. | COM | 29384C108 | 37,335,293 | 0.19 | 5072730.0 |
| FTH | Faeth Therapeutics, Inc. | COM | 81728A207 | 32,160,275 | 0.16 | 1286411.0 |
| AKTS | Aktis Oncology, Inc. | COM | 01021M104 | 32,112,393 | 0.16 | 996351.0 |
| NGNE | Neurogene Inc. | COM | 64135M105 | 31,188,682 | 0.16 | 991691.0 |
| JBIO | Jade Biosciences, Inc. | COM | 008064206 | 27,340,066 | 0.14 | 1230426.0 |
| TSHA | Taysha Gene Therapies, Inc. | COM SHS | 877619106 | 27,272,388 | 0.14 | 4004756.0 |
| RCUS | Arcus Biosciences, Inc. | COM | 03969F109 | 26,045,677 | 0.13 | 844816.0 |
| IRON | Disc Medicine, Inc. | COM | 254604101 | 25,573,913 | 0.13 | 349657.0 |
| ABSI | Absci Corporation | COM | 00091E109 | 24,742,367 | 0.12 | 2134803.0 |
| GENB | Generate Biomedicines, Inc. | COM SHS | 370920100 | 24,016,166 | 0.12 | 1423602.0 |
| DBVT | DBV Technologies S.A. | SPONSORED ADS | 23306J309 | 23,967,370 | 0.12 | 1461425.0 |
| XENE | Xenon Pharmaceuticals Inc. | COM | 98420N105 | 22,345,755 | 0.11 | 370208.0 |
| TECX | Tectonic Therapeutic, Inc. | COM | 878972108 | 20,892,713 | 0.1 | 607788.0 |
| CERS | Cerus Corporation | COM | 157085101 | 18,674,659 | 0.09 | 6395431.0 |
| CTMX | CytomX Therapeutics, Inc. | COM | 23284F105 | 18,659,348 | 0.09 | 4975826.0 |
| DYN | Dyne Therapeutics, Inc. | COM | 26818M108 | 18,066,702 | 0.09 | 813449.0 |
| CYTK | Cytokinetics, Incorporated | COM | 23282W605 | 17,997,836 | 0.09 | 211267.0 |
| XNCR | Xencor, Inc. | COM | 98401F105 | 17,743,907 | 0.09 | 1102106.0 |
| SION | Sionna Therapeutics, Inc. | COM | 829401108 | 17,596,000 | 0.09 | 400000.0 |
| NTLA | Intellia Therapeutics, Inc. | COM | 45826J105 | 15,739,525 | 0.08 | 930232.0 |
| PBLS | Parabilis Medicines, Inc. | COM | 698955101 | 13,685,000 | 0.07 | 500000.0 |
| MPLT | MapLight Therapeutics, Inc. | COM | 56565P103 | 13,071,027 | 0.07 | 364705.0 |
| AVLN | Avalyn Pharma Inc. | COM SHS | 05348Y105 | 11,522,000 | 0.06 | 350000.0 |
| EVMN | Evommune, Inc. | COM SHS | 30054Y107 | 11,261,813 | 0.06 | 847390.0 |
| BNTX | BioNTech SE | SPONSORED ADS | 09075V102 | 11,142,086 | 0.06 | 119743.0 |
| TNGX | Tango Therapeutics, Inc. | COM | 87583X109 | 10,419,990 | 0.05 | 333333.0 |
| AVTX | Avalo Therapeutics, Inc. | COM | 05338F306 | 10,164,000 | 0.05 | 550000.0 |
| SERA | Sera Prognostics, Inc. | CLASS A COM | 81749D107 | 10,006,669 | 0.05 | 5498170.0 |
| VSTM | Verastem, Inc. | COM | 92337C203 | 9,547,471 | 0.05 | 2499338.0 |
| SGMT | Sagimet Biosciences Inc. | COM SER A | 786700104 | 7,366,659 | 0.04 | 952996.0 |
| EIKN | Eikon Therapeutics, Inc. | COM | 282564103 | 7,249,993 | 0.04 | 555555.0 |
| LBRX | LB Pharmaceuticals Inc. | COM SHS | 50180M108 | 6,491,000 | 0.03 | 200000.0 |
| VTVT | vTv Therapeutics, Inc. | CL A | 918385204 | 5,584,022 | 0.03 | 148314.0 |
| WVE | Wave Life Sciences Ltd. | SHS | Y95308105 | 4,779,527 | 0.02 | 822638.0 |
| TARA | Protara Therapeutics, Inc. | COM STK | 74365U107 | 3,711,565 | 0.02 | 971614.0 |
| TCRX | TScan Therapeutics, Inc. | COM | 89854M101 | 2,729,375 | 0.01 | 2784792.0 |
| IMNM | Immunome, Inc. | COM | 45257U108 | 1,171,934 | 0.01 | 55306.0 |
| SKYE | Skye Bioscience, Inc. | COM | 83086J200 | 1,092,116 | 0.01 | 1575243.0 |
| SANA | Sana Biotechnology, Inc. | COM | 799566104 | 1,083,586 | 0.01 | 310483.0 |
| ALGS | Aligos Therapeutics, Inc. | COM | 01626L204 | 479,227 | 0.0 | 83055.0 |
| TYRA | Tyra Biosciences, Inc. | COM | 90240B106 | 338,788 | 0.0 | 10607.0 |
| - | Surrozen, Inc. Warrants @ $172.50 8/11/2026 (15 FOR 1) | W EXP 8/11/2026 | 86889P117 | 13,750 | 0.0 | 833333.0 |
Quarterly portfolios
| Period | Filed | Value ($) | Positions | Vol % | Beta | Max DD % |
|---|---|---|---|---|---|---|
| 2026-06-30 | 2026-08-14 | 19,955,238,553 | 84 | 16.003215 | 0.363987 | 28.002073 |
| 2026-03-31 | 2026-05-15 | 17,415,689,929 | 84 | 15.764458 | 0.351447 | 25.455759 |
| 2025-12-31 | 2026-02-17 | 17,078,624,105 | 86 | 15.588808 | 0.351218 | 24.76135 |
| 2025-09-30 | 2025-11-14 | 13,838,782,047 | 91 | 15.816667 | 0.344738 | 22.093501 |
| 2025-03-31 | 2025-05-15 | 9,036,702,464 | 89 | 13.61986 | 0.313404 | 23.055706 |
| 2024-12-31 | 2025-02-14 | 9,361,492,374 | 95 | 14.39013 | 0.330609 | 24.116938 |