| OLDAKOWSKI MARK |
|
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
27,737 |
|
27,737 |
| Olivan Javier |
Officer |
2/2/2026 |
Automatic Sell |
Direct |
517 |
$714.60 |
9,615 |
| Oliver Lawrence T. |
Officer |
2/2/2026 |
Buy |
Direct |
9 |
$22.22 |
29,768 |
| Oliveto Joseph |
|
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
1,132,000 |
|
679,000 |
| Olson Anne |
Officer |
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
1,050 |
|
27,931 |
| Olson Anne |
Officer |
2/2/2026 |
Disposition (Non Open Market) |
Direct |
322 |
$63.83 |
27,609 |
| Oltmans Curtis Gale |
|
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
170,000 |
|
170,000 |
| Opaleye Management Inc. |
10% Owner |
2/2/2026 |
Buy |
Indirect |
100 |
$58.00 |
450,944 |
| OrbiMed Capital GP VIII LLC |
Director |
2/2/2026 |
Automatic Sell |
Indirect |
1,890 |
$44.57 |
3,559,765 |
| Orf David L |
Officer |
2/2/2026 |
Disposition (Non Open Market) |
Direct |
964 |
$53.23 |
22,319 |
| OShaughnessy Robert |
Officer |
2/2/2026 |
Disposition (Non Open Market) |
Direct |
7,210 |
$125.44 |
57,054 |
| OSSOWSKI JAMES L |
Officer |
2/2/2026 |
Disposition (Non Open Market) |
Direct |
1,804 |
$125.44 |
11,943 |
| Ostrowski Erik |
|
2/2/2026 |
Automatic Sell |
Direct |
34,951 |
$1.39 |
672,635 |
| Ottinger Eric H |
Officer |
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
2,047 |
|
36,929 |
| Ottinger Eric H |
Officer |
2/2/2026 |
Disposition (Non Open Market) |
Direct |
1,536 |
$60.76 |
35,393 |
| PAGE G RUFFNER JR |
|
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
243 |
$102.97 |
81,410 |
| Palmby Paul Laurence |
Director |
2/2/2026 |
Acquisition (Non Open Market) |
Direct |
775 |
$43.58 |
5,585 |
| Palmer Stephen R |
Officer |
2/2/2026 |
Automatic Sell |
Direct |
1,000 |
$393.04 |
37,192 |
| Paquin Natalye |
Director |
2/2/2026 |
Buy |
Direct |
580 |
$34.58 |
29,932 |
| Parel Dinu J |
Officer |
2/2/2026 |
Option Execute |
Direct |
3,030 |
$296.00 |
9,564 |
| Parel Dinu J |
Officer |
2/2/2026 |
Disposition (Non Open Market) |
Direct |
1,714 |
$949.40 |
7,850 |
| Parel Dinu J |
Officer |
2/2/2026 |
Sell |
Direct |
1,316 |
$950.05 |
6,534 |
| Parel Dinu J |
Officer |
2/2/2026 |
Option Execute |
Direct |
3,030 |
|
0 |
| Parker Douglas Michael |
|
2/2/2026 |
Option Execute |
Direct |
5,864 |
|
3,449 |
| Parker Douglas Michael |
|
2/2/2026 |
Disposition (Non Open Market) |
Direct |
3,140 |
$286.98 |
1,122 |